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Related studies using growth hormone as a ligand confirmed that this JAK2-independent pathway can activate ERK1/2 through the activation of Ras-like small GTPases, RalA, and RalB in NIH-3T3 cells and through the activation of Rap1 and Rap2 (111, 112)

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Hypoxic preconditioning results in increased motility and improved therapeutic potential of human mesenchymal stem cells