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Defects in the OCTN2 gene cause primary carnitine deficiency, further emphasizing the strategic position of OCTN2 in maintaining carnitine homeostasis [165]

The 2026 EASO pharmacotherapy update explicitly ranks tirzepatide above semaglutide for weight loss, while supporting semaglutide as the better-documented option for liver fibrosis endpoints in MASH [1]

In contrast, in obese human subjects under fasting conditions, the increase in urinary excretion of acetylcarnitine was markedly slower and at a lower level, suggesting a slower formation of acetyl-CoA derived from fat oxidation

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