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We critically evaluate the emerging evidence demonstrating that MSC Exos are enriched with anti-ferroptotic miRNAs, antioxidant enzymes, and iron homeostasis regulators, which can mitigate cellular ferroptosis

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Firstly, there is the ERS pathway mediated by PERK, where TMAO directly binds to and activates PERK, triggering the PERK-eIF2-ATF4-CHOP axis

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ORegan GC, Farag SH, Ostroff GR, Tabrizi SJ, Andre R