As with other incretin-based therapies, the most frequently reported side effects of retatrutide particularly in the early stages of treatment are gastrointestinal in nature
10.1038/s41433-023-02908-y [DOI] [PMC free article] [PubMed] [Google Scholar] 36.Azzam AY, Essibayi MA, Vaishnav D et al (2025) Liraglutide for idiopathic intracranial hypertension: a real-world propensity scorematched study
It also slows the digestion process, so food stays in your stomach longermaking you less compelled to snack in between meals
However, more large-scale randomized controlled trials (RCTs) are required to verify the neuroprotective effects of metformin
While GLP-1 agonists primarily work through appetite suppression (the input side of the energy equation), glucagon activation works on the output side, increasing how many calories the body burns at rest
They can provide personalised advice based on your children's health profiles