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Effects of Tirzepatide, a dual GIP and GLP-1 RA, on lipid and metabolite profiles in subjects with type 2 diabetes

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The authors found that GLP-1 secretion was weaker after 60 min digests with pepsin in rice endosperm protein hydrolysates than after 30 min digests, which suggests that oligo- or larger peptides, rather than small peptides or free amino acids, might be responsible for this stimulation