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Immunity 57 , 649673 (2024)

Dietary modifications can also prove beneficial: Drink plenty of water throughout the day to stay well-hydrated and help flush the mouth Occasionally use sugar-free mints or chew sugar-free gum to stimulate saliva production (though use these moderately if you experience diarrhoea) Eat small, frequent meals rather than large portions to minimise gastrointestinal symptoms that may worsen taste changes Avoid strongly flavoured or spicy foods if they exacerbate the unusual taste Try cold or room-temperature foods, which may be better tolerated than hot meals Rinse your mouth with water before eating to help neutralise any persistent taste Timing considerations may help as well

Second, sublingual bioavailability varies between doses for the same individual

& Mendez-Sanchez, N

Separately, a case series published in Clinical Toxicology in March 2026 documented five cases of severe hypotension and syncope (fainting) in individuals who combined Melanotan-2 with PDE5 inhibitors like sildenafil

Vomiting, while less common than nausea, can also occur