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Administration of exogenous GLP-1 (but not GIP) leads to a significant increase in endogenous insulin secretion

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However, diagnosing depression is challenging since there are no validated biological tests, and treatment decisions often rely on subjective reports from patients

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Existing preclinical and clinical evidence links GLP-1 receptor agonist use with differing effects across major eye diseases, showing a generally consistent association with reduced glaucoma incidence, mixed and nuanced findings in diabetic retinopathy, and divergent signals in age-related macular degeneration (AMD) depending on disease subtype