T-lymphocytes of Hodgkins disease have low expression of fas ligand and CD30 ligand which can be unregulated by interferon-a and anti CD3
This highlights the importance for men who are looking to conceive to ensure that their levels are adequate before conception happens to avoid any fertility issues that a deficiency can cause
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The successful combination of this model with the redox cycling model was proven by recapitulation of Figs 2 and 6 from the Reed et al