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As a result, there is growing interest in incorporating physiologic traits such as loop gain, arousal threshold, and upper airway responsiveness into assessment frameworks to better guide individualized treatment strategies

Physical activity should reach at least 30 minutes of moderate intensity on most days

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This central mechanism is distinct from PDE5 inhibitors like sildenafil, which act peripherally on vascular smooth muscle

This integrative approach allows us to characterize immune-metabolic signatures associated with L-serine treatment in ASD, establishing a basis for identifying novel peripheral therapeutic targets