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Tumour heterogeneity and dynamic changes in miRNA expression during disease evolution or treatment further undermine their utility as stable biomarkers or therapeutic targets

Adverse Reactions (6.1).] Sitagliptin Add-on Therapy in Patients with Type 2 Diabetes Inadequately Controlled on the Combination of Metformin Immediate-Release and Rosiglitazone A total of 278 patients with type 2 diabetes participated in a 54-week, randomized, double-blind, placebo-controlled study designed to assess the efficacy of sitagliptin in combination with metformin immediate-release and rosiglitazone

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At 12 months post-GLP-1RA-initiation, the concomitant use of anti-diabetes agents was as follows: metformin, SGLT2 inhibitors, insulin, sulfonylureas, -glucosidase inhibitors, glinides, and thiazolidinediones ( Table 2 )