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Adding intense exercise stress on top risks overtraining symptoms, excessive fatigue, and potential muscle catabolism

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A baseline fasting insulin and HOMA-IR assessment should precede GLP-1 selection discussions with your provider

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Surgery confers multiple downstream benefits: Lower rates of obesity-related comorbidities (like hypertension, hyperlipidemia, sleep apnea) compared to GLP-1 therapy at follow-up JAMA Network Reduced health care utilization: fewer inpatient stays, outpatient visits, and ED visits per patient per month post-surgery compared to GLP-1 therapy