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However, as we also note in response to a subsequent comment, we agree that the regulations should more explicitly specify the types of practices that will be prohibited under our finalized policy

CagriSema produced unprecedented mean weight loss of 20.4% at 68 weeks on an intent-to-treat basis, significantly exceeding semaglutide alone (14.9%), cagrilintide alone (11.5%), and placebo (3.0%)