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Market response: Novo Nordisk shares declined by approximately 15% following the announcement, underscoring how sensitive the obesity market is to comparative efficacy data

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All primer sequences are listed in Supplementary Table 1

258,259 Intracytoplasmic sperm injection results in successful pregnancy and birth in about 30% of cases overall, and evidence suggests sperm DNA fragmentation may play a role in limiting positive outcomes

The commenters also requested that CMS update the NTIOL payment annually going forward

(2023b)