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Kayaniyil S, Lozano-Ortega G, Bennett HA, et al

Nature Medicine Al-Aly et al

The GLP-1 component slows gastric emptying and reduces appetite by signaling satiety to the brain

Retatrutide is appropriate for adults with type 2 diabetes or obesity when initiated and monitored by a qualified healthcare provider

The pattern in trials has been broadly consistent with other incretin-based therapies (such as Mounjaro and Wegovy), and most side effects have been mild to moderate and dose-dependent, occurring mainly during the initial dose-escalation period

Ask whether the product claims to increase GLP-1 production from L-cells, reduce DPP-4 degradation, increase GLP-1 receptor sensitivity, or something else entirely