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2013;36(1): e8

The nanozyme exhibits high multi-enzyme mimetic activities, including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) functionalities, enabling effective maintenance of redox homeostasis for osteoarthritis (OA) treatment

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To test this, we inhibited the cysteine/glutamate antiporter System Xc - using Imidazole Ketone Erastin (IKE), thereby limiting substrate availability for GSH synthesis ( Figure 6H )