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It was demonstrated that GLP-1 brain administration elevated the circulating concentrations of the adrenocorticotropic hormone (ACTH) and corticosterone and also enhanced anxiety in behavioral measurements [75]

Watch for signs of degradation: Discard if cloudy, colored, crystallized, or viscous, or if injection sites show redness, swelling, or pain

Using low dead volume syringes or syringes with integrated needles minimizes this loss

Patient counseling on slow titration and proper nutrition is paramount

Many patients report this is when they truly start believing the medication is working

the delay allows these mechanisms to activate