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James MO, Jahn SC, Zhong G, Smeltz MG, Hu Z, Stacpoole PW

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Headache Mild stomach upset Flatulence Nausea and vomiting Patients with bipolar disorder may develop mania Patient Warnings: Patients taking selective serotonin reuptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants, or other drugs that affect serotonin levels should avoid taking SAM-e without the supervision of a physician due to case reports of mania and serotonin syndrome, a serious condition, or other side effects

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