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The intensity of this consequence can vary, with some people noticing it mildly and other experiencing some abdominal discomfort, especially when first starting or increasing the dose

Unlike many other glucose-lowering drugs, GLP-1 receptor agonists dont come with a relative contraindication for renal impairment

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Previous studies in drug-nave rodents showed that activation of GLP-1-producing NTS neurons that project to the VTA transiently reduced food intake 28