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Furthermore, an interventional clinical trial revealed recently the amelioration of AAC was not followed by an increase or decrease in the sKlotho level in MHD patients with secondary hyperparathyroidism, which further challenged the clinical value of sKlotho in VC (Chou et al., 2019) The inconsistent studies were summarized and the average score was 6.6 stars, as shown in Table 4

Phase 3 TRIUMPH-4 showed 28.7% weight loss at 68 weeks, substantially exceeding CagriSema's 20.4% at 68 weeks