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GLP 1 receptor agonists and dual incretin therapies are delivering measurable, outcome driven results: 12% to 27% relative risk reduction in major adverse cardiovascular events across CVOTs 13% to 14% reduction in cardiovascular death in meta analyses 11% to 14% reduction in hospitalization for heart failure 24% relative risk reduction in kidney outcomes in the dedicated FLOW trial with semaglutide Up to 15.8% weight loss with semaglutide 2.4 mg 20.2% weight loss with tirzepatide 15 mg in head to head obesity trials 66% to 93% reduction in progression from prediabetes to type 2 diabetes This is no longer about glucose (or weight loss) alone
If you do frequent weight lifting or high-intensity training, protein needs are higher still (commonly in the 1.21.7+ g/kg range for serious strength athletes)
Biochim Biophys Acta 1780(11):13621367
Patients and healthcare providers should engage in open dialogue about the potential side effects, and ongoing monitoring is essential to ensure the safe and effective use of Wellbutrin in treating depression
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