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Notably, mitochondrial dysfunction is closely linked to NLRP3 inflammasome activationbone marrow-derived macrophages deficient in Lcn2 exhibit reduced mitochondrial damage, accompanied by diminished NLRP3 activation and decreased IL-1 production [126]

Given the complexity of the disease and prior unsuccessful clinical trials, we need to think outside the box to make strides for our patients, says Skylar-Scott

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A clustered plasticity model of long-term memory engrams

- Feeling disoriented about time or date, especially in unfamiliar or new environments