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[11] In April 2026 the sponsor announced that SYNCHRONIZE-1 a double-blind, placebo-controlled study of roughly 725 adults with obesity or overweight without diabetes met its co-primary endpoints, reporting mean bodyweight loss of about 16.6% at 76 weeks versus about 3.2% on placebo, with a large proportion of participants achieving at least 5% weight loss

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Since it does not include the DAC component, it breaks down faster, allowing researchers to observe short-term hormone activity and regulatory responses more clearly

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Secondary resistance in patients who showed an initial response has actually been thought to be due to de novo mutations located on regions in smoothened to which hedgehog pathway inhibitors bind or selective clonal expansion of minority clones in the pre-treated tumor