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Warning signs include: Sudden rash or hives spreading across the body Generalized itching that is not isolated to the application site Swelling of the face, lips, tongue, or throat Difficulty breathing or shortness of breath Symptoms suggestive of a severe allergic reaction (anaphylaxis) require prompt medical attention

10.1111/j.1582-4934.2008.00478.x 63 RotheF.SchmidtW.WolfG