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These receptors are conserved across a wide range of organisms, from ctenophores to vertebrates, and contribute to neuronal signalling, development, and plasticity in early-diverging lineages such as Hydra (Pierobon 2012)

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In alveolar myofibroblasts, PRMT7 was shown to monomethylate histone H4 (H4R3me1) at the Forkhead box M1 (Foxm1) promoter, activating its transcription and promoting myofibroblast proliferation and elastin deposition

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