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The synthesis of glutathione involves two enzymatic steps, both requiring ATP hydrolysis for energy supply

Acta Physiol Scand 2003;179:233241

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Excess ROS then activates the NLRP3 inflammasome in microglia, promoting maturation and release of IL-1 (Xiao et al., 2021)

Insulin, Glucose, Insulin Resistance, and Pancreatic Cancer in Male Smokers

Initially, the carboxylate group on -glutamylcysteine is converted into an acyl phosphate by the transfer of an inorganic phosphate group of ATP to generate an acyl phosphate intermediate