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Glial paralysis opens the gate for neurodegeneration and other diseases of old age

Whereas COX-1 acetylation by aspirin abolishes its enzymatic activity, COX-2 acetylation modifies the enzyme in such a way that it performs an incomplete reaction ultimately resulting in the generation of lipoxins (Claria and Serhan, 1995), which inhibit cancer cell proliferation and angiogenesis (Ferrandez et al, 2012)

Pujos-Guillot et al., 2012

Cefaclor causes vagus nerve-mediated depression-like symptoms with gut dysbiosis in mice

Increased risk of high-grade prostate cancer among infertile men

At a fundamental level, most glial responses to pathology are adaptive and allostatic favouring recovery and regeneration rather than destruction