however, meta-analysis suggests physical trauma and psychologic stress are possible environmental triggers of GD (76)
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Common and Systemic Side Effects Gastrointestinal Issues: The most common side effect of oral supplementation is mild, transient gastrointestinal (GI) discomfort, which can include mild bloating, cramping, loose stools, or general stomach upset
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Nonetheless, the aforementioned animal models, although extremely useful in investigating specific molecular mechanisms in the pathogenesis of ulcerative colitis, do not truly recapitulate disease as observed in patients, as IBD is a multifactorial disease and most clearly is not caused by a single mutation or defect in cellular or molecular pathways