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GLP-1s and Hypogonadism A small study found that GLP-1s administered to overweight or obese men with diabetes improved testicular function, primarily through weight reduction and by rebalancing the suppression of the HPG axis caused by obesity

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(107) demonstrated that even though prednisolone increased serum total and bioactive IGF-I, post-IGF-IR signaling was inhibited indicating that prednisolone-induced increases in serum IGF-I levels is not accompanied by increased IGF-I action

The post points at people already taking insulin or other glucose-lowering medications, where an increase in alcohol intake amplifies the risk

Interaction between 5-HTTLPR genotype and cognitive stress vulnerability on sleep quality: effects of sub-chronic tryptophan administration