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These initial studies reported increased NAD + and NAM levels in plasma, and in urine, the excreted NAD + levels increased after 6 h 66 , but it must be noted that these trials utilized small cohorts and short testing periods, and only a minor trend for cognitive improvement was observed 117

Thanks again to Benjy Renton for help wrangling the data informing this post.

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Randomized clinical study: partially hydrolyzed guar gum (PHGG) versus placebo in patients with irritable bowel syndrome