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Damage to the protective lining of the blood vessels ensues, as well as pathologic changes to kidney cells and kidney function

N Engl J Med [Internet]

GSH research spans four primary functional domains: direct antioxidant defence, enzymatic cofactor activity, redox signal transduction, and xenobiotic detoxification

doi: 10.1159/000489913

Additionally, exposures such as cigarette smoke, agricultural chemicals, organic and inorganic dusts, and air pollution are associated with increased IPF risk, likely by exacerbating epithelial damage and promoting aberrant repair [20, 28]

Given its involvement in regulating mitochondrial glutathione (GSH) levels, both SLC25A39 and mitochondrial GSH emerge as potential therapeutic targets for CRC