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The same finding had been reported by a prior larger meta-analysis (6,914 patients with overweight or obesity and T2DM) over 8 studies 184,185,189,190,191,192,193,194 , but only when the largest study that also included non-diabetic participants 193 was excluded in a sensitivity analysis 195

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Timing considerations Take the capsule with your largest meal of the day if possible

Long-term hyperglycemia can contribute to persistent disturbances in glutamatergic signaling and neural damage in the medial prefrontal cortex, contributing to depressive behaviors [91]

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However, this particular rat strain is also widely regarded as a valid model of endogenous depression [117]