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10.1165/rcmb.2009-0169TR [DOI] [PMC free article] [PubMed] [Google Scholar] Zhang H., Forman H.J., and Choi J

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Locus rs225014, which confers risk to OA, was associated with the differential methylation of CpG located in the upstream region of DIO2 gene and was correlated with upregulated DIO2 expression in OA 104

The method involved intracellular oxidation of non-fluorescent dye dihydrorhodamine-(DHR)-123 to the fluorescent rhodamine-123 (R123) caused by free radicals and hydrogen peroxide