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When you eat, GLP-1 is released, prompting the pancreas to produce insulin

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Effective transdermal drug delivery generally requires appropriate lipophilicity and molecular propertiesberberine's physicochemical characteristics are suboptimal for this route, primarily due to its ionic charge and poor lipid solubility

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10-13 In subsequent trials where higher doses of the GLP-1/GIP agonists were used in non-diabetic obese subjects, weight loss of 15% to 21% of body weight was seen

However, the incidence of gastrointestinal events, discontinuations due to adverse events, and mean increase in pulse rate were higher with orforglipron than oral semaglutide