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Inflammatory Response By invigorating the immune system, B12 might lead to a temporary spike in inflammation, which is essentially a marker that healing mechanisms are in play

doi: 10.1016/j.cell.2018.08.049 111

Martn ED, Snchez-Perez A, Trejo JL, et al

But he could have gotten something new on a trial if it was covered by his companys health plan

Antibodies for BECN1 (Beclin), Bax, pERK1/2 (T202/Y204, T185/Y187), PARP/cleaved PARP, p47Phox, IRE1, pAKT (S473) and -actin (1:500, Santa Cruz Biotechnology, Santa Cruz, California, USA)

They dont happen often, but its still good to know what to watch for