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In turn, analysis of collagen deposition by sirius red staining demonstrated that uric acid injection led to increased collagen deposition in WT, but not in Myd88 / and Nlrp3 / mice (Fig

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Apoptosis was also confirmed by the accumulation of the proapoptotic proteins p53 and p27, and by cleavage of full-length PARP (poly (ADP-ribose) polymerase), primarily in Ru II -02 at 24 h of treatment

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This was seen in mice that were treated with 5 Amino 1 MQ, in which large-sized myofibers were observed as compared to the controls