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Non-negotiable targets: Protein: 80-100g daily minimum (prevents muscle loss during weight loss) Calories: Dont go below 1,200 (women) or 1,500 (men) despite suppressed appetite Fiber: 25-35g daily (prevents constipation, supports gut health) Healthy fats: 30-50g daily (prevents gallbladder issues during rapid weight loss) Meal structure moving forward: Still smaller frequent meals (5-6 per day)

However, off-label use for lower BMIs is possible when there's a clinical rationale

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Wnt3a, -catenin, PCNA, Cyclin D1, and VEGF increased in dorsal skin on day 13, as detected by WB