Although STAT members including STAT1, 3, and 5 are activated by JAK2 following GH induction (Figure 3), STAT5 is the predominant transcription factor that delivers GH-induced cell proliferation and actions
Trying to restart at your previous therapeutic dose would likely cause significant side effects similar to starting at a high dose initially
[DOI] [PubMed] [Google Scholar] Leipert J., Treitz C., Leippe M., Tholey A
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Your body does its most significant "cleanup" work while you sleep