In conclusion, tirzepatide increased blood pressure and sympathetic activity in hypertensive rats without cardiac protection, highlighting context-dependent cardiovascular actions

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Kobori T, Onishi Y, Yoshida Y, Tahara T, Kikuchi T, Kubota T, et al
Evaluation of the pharmacokinetics and safety of AMG 986 tablet and capsule formulations in healthy adult subjects: a phase I, open-label, randomized study
Also, biochemical evidence has indicated that the TKTL1 protein does not catalyze a transketolase reaction