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In the kidneys, GLP-1RAs lower urea, creatinine, and pro-inflammatory cytokines via AMPK-dependent pathways, supporting renal function during sepsis-induced acute kidney injury

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Most side effects are mild, like nausea or constipation, and usually decrease as treatment continues

Some of the inconsistency across preclinical reports reflects differences in the compounds, doses, and assay conditions used, so standardised reporting of peptide characterisation and experimental conditions would make the literature easier to interpret and to replicate

Only the albumin variants with an isoleucine (L585I), a methionine (L585M), or a valine (L585V) showed binding curves similar to that obtained for the WT albumin (Fig

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