Timestamps 00:00 Cold open: 200 years of menopause medicine 03:23 Welcome and roadmap 04:20 The HPG axis, follicles, and the FSH lag 09:11 STRAW+10 staging and the timing of perimenopause 13:47 Austin: the 49-year-old with a hormone panel 20:00 Loraine: the OB-GYN workup 28:00 Symptom attribution: what menopause actually causes 33:46 Austin: the all-estrogen patient 37:58 VMS duration and the KNDy mechanism (Avis, SKYLIGHT) 43:53 Austin: who actually gets fezolinetant 47:22 The WHI 24-year correction (Manson, Chlebowski, Boardman) 01:00:15 Modern prescribing today 01:06:52 Where the menopause-content space gets it right and wrong 01:11:50 Testosterone, compounded bioidenticals, and DUTCH panels 01:24:13 Takeaways What we cover The HPG axis and the estrogen shield: what is happening across the 35-year reproductive era and what changes at perimenopause
When a product says copper peptides on the front, GHK-Cu is almost always the star
Laage, D., Elsaesser, T
A randomized, double-blind, placebo-controlled trial of Schisandra chinensis for menopausal symptoms
Whether it's the result of athletic training, repetitive movements, long hours of sedentary work, or the inevitable effects of aging, more and more individuals are struggling with issues like: Ongoing joint and tendon strain Delayed post-exercise recovery Persistent muscle fatigue or tightness Digestive sensitivity and gut imbalances Generalized inflammation or discomfort Why Traditional Solutions Are Falling Short The majority of conventional supplements in the wellness and recovery category-like glucosamine, collagen, turmeric, or basic multivitamins-aren't designed to address cellular signaling or peptide-related repair mechanisms directly
Mark Haupt, MD, shares insights from his work in research, academia, and the pharmaceutical industry
