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doi: 10.1056/NEJMoa1812389 10 NealBPerkovicVMahaffeyKWde ZeeuwDFulcherGEronduNet al

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Solution: Why Form Matters Lyophilized (dry) peptides More resistant to degradation Lower microbial risk Suitable for short-term room temperature conditions Best option for shipping or handling Reconstituted peptides Rapidly lose stability Vulnerable to contamination Sensitive to pH, buffer components, and light Should be kept cold whenever possible Practical Room Temperature Handling Tips Equilibrate vials before opening Allow frozen or refrigerated vials to reach room temperature while sealed

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