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For example, INT-777 and MN6, TGR5 selective agonists, stimulated GLP-1 secretion and improved insulin sensitivity in diet-induced obesity (DIO) mice [180, 181]

However, the medications also have significant side effects, including unintended muscle mass loss, nutritional deficiencies, a potential for increased risk of miscarriage or birth defects, and severe mental health issues like depression and suicidal thoughts

On one hand, these medications can help you manage your blood sugar and lose weight, but on the other hand, they can come with some unpleasant side effects

Tuttle KR, Lakshmanan MC, Rayner B, et al

Additionally, the patient will demonstrate understanding of key factors that can impact glucose stability

These symptoms are usually most pronounced 13 days after injection and typically diminish significantly after 48 weeks as tolerance develops