Unlike many other vitamins, B12 is stored in the liver in substantial quantities, meaning deficiency typically develops gradually over months to years as these reserves become depleted
Continuous daily dosing maintains steady-state synaptogenesis, while cyclic protocols (5 days on, 2 days off, or 4 weeks on, 1 week off) are used to assess whether newly formed synapses persist after Dihexa withdrawal
It is also commonly fortified in foods, such as cereals, non-dairy milks, and nutritional yeast
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Se ha identificado qumicamente como el componente presente en el producto comercializado como TB-500 (PMID 22962027)
Nephrourol Mon 2013;5:655667