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The GLP-1R agonist exenatide has been shown to have little effect on food intake in leptin deficient mice and leptin receptor null rats, whilst leptin can strongly enhance the anorectic effects of exenatide in the latter ( Supplementary Figure S1E )

A 0.2mL dose converts to 0.2 100 = 20 units

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However, other factors such as cost, side effects, and individual response to the medications should also be taken into consideration when making a decision

Model it as a discrete financial opportunity per target

This narrative review provides a comprehensive overview of the diverse modeling approaches, critically evaluating their strengths and limitations