what hormones does glp 1 affect Major physiological roles of GLP-1 and GIP. Tirzepatide is acting as an GIP and GLP‐1, the two

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11 Additionally, GLP-1R activation also induces the translocation to the nucleus of the PDX-1 transcription factor, giving GLP-1 a role in islet beta-cell survival

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Because of lack of sensitivity and problems with non-specificity of commercially available GLP-1R antisera detected multiple nonspecific immunoreactive proteins even in tissue extracts from Glp1r -/- mice