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Succinate Modulation of Immune Functions As discussed in detail in the Metabolic Alterations Associated with Cancer page, and briefly above, increased levels of succinate in the cytosol result in the inhibition of the PHD enzymes that hydroxylate, and thereby destabilize, the HIF-1 subunit of the HIF-1 transcription factor complex

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In the last years there has been a significant increase in knowledge of the use of glucagon-like peptide 1 receptor agonist (GLP1-RA) agonists in the treatment of T2DM and obesity or overweight