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A human genetic disease characterized by CPT2 deficiency leads to elevated acylcarnitine levels in serum caused by impaired FAO

Intervention studies consistently show that supplementation with folic acid, particularly alongside vitamins B6 and B12, lowers homocysteine regardless of MTHFR genotype

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Although anti-IGF-IR mAbs and IGF-IR inhibitors have potent anti-cancer effects in preclinical models, clinical trials of these agents are largely disappointing in unselected cancer patients

The pivotal role of ApoE lies in the redistribution of cholesterol and phospholipids to neurons through its interaction with cell-surface ApoE receptors