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We know that compounded medications filled a critical gap during shortages, both Novo and Eli Lilly are now ramping up manufacturing and online distribution, which is likely to squeeze compounders market share going forward

These effects explain why gastrointestinal side effects are among the most commonly reported adverse reactions to GLP-1 therapy

What this means for patients The practical issue is not Should all patients stop GLP-1 drugs? The better question is: Do I already have diabetic retinopathy, and do I need a retinal exam or closer follow-up while my diabetes treatment is being intensified? Who Needs Extra Eye Monitoring

Funding The author(s) declare that no financial support was received for the research and/or publication of this article

EECs originate from Leucine-rich repeat containing G protein-coupled receptor (Lgr5) positive stem cells in the base of the intestinal crypts

But semaglutide is a large molecule