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The body produces its own glutathione, but levels may be depleted by poor diet, pollution, toxins, stress, ageing and infections

This deficiency may contribute to the oxidative stress and inflammation that are characteristic of the disease

It is also investigated in oxidative stress and cellular defense pathways, where it helps model how peptide signaling interacts with antioxidant systems and metabolic regulation

Interestingly, similar to CuPDTC, ZnPDTC also triggers proteasome inhibition and PARP1 cleavage (Milacic et al., 2008), raising questions about whether and how CuPDTC and ZnPDTC bind to the 20S proteasome

Many of these impact the brain by one of two ways (or both)

People who adhere to vegan or vegetarian diets are at higher risk of deficiencies of NAD+ and glutathione