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While Nrf2 and JAK2/STAT3 are indeed activated as protective responses during MIRI, the overwhelming and dynamic nature of the oxidative insult often impairs their full protective capacity or overwhelms the defense mechanisms they regulate, leading to a functional failure in restoring redox balance

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It can mistakenly begin attacking healthy tissue

Such dramatic enhancement in locomotor behavior further emphasized the critical roles of DAT-mediated reuptake in the termination of dopaminergic neurotransmission